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If you are using a locale definition that recognizes characters that are not in the standard US ASCII character set, you might have difficulty sending mail to a user on a system that is using a different locale (or one that does not recognize locales). Characters outside the core of alphanumeric characters common to ISO8859-1 might be ignored or mistranslated under other locales.
More problematically, if your user name or machine name contains an 8-bit character, a user on a 7-bit system cannot send any messages to you because they cannot input the 8-bit character in the address. Therefore, it is important not to create user names containing 8-bit characters.